4th Best Mass Effect Decision: Rewrite or destroy the heretics
It's a horrible, messy way to end this mission chain and I don't see what incentive any player who was attached enough to Wrex to save him on Virmire would have to take this path. However, if either Eve or Wrex are alive, then the only way you can sabotage the cure is to kill Mordin yourself - and Wrex later discovers your subterfuge, forcing you to kill him as well. Now, if you're only doing this because you want to save Mordin in a playthrough with Wreav, taking this option is a bit more forgivable. A Salarian leader (who you don't know, by the way) contacts you and offers you help if you instead sabotage the cure so the genophage remains.
Depending on whether you save Wrex on Virmire, either he or his brother Wreav will be the krogan leader on Tuchanka who demands you cure the genophage to earn the Krogan's help. I'm starting the worst list with a choice that's confusing under a particular set of circumstances, albeit ones that I think most players will be likely to have for their playthroughs.
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